Standardization study of snake skin Boa constrictor as a model membrane for percutaneous drug release

Authors

  • R. S. Nunes Laboratório de Farmacotécnica, Universidade Federal de Sergipe
  • J. R. Azevedo Laboratório de Farmacotécnica, Universidade Federal de Sergipe
  • A. P. Vasconcelos Laboratório de Farmacotécnica, Universidade Federal de Sergipe
  • N. L. Pereira Programa de Pós-graduação em fármacos e medicamentos da Universidade de São Paulo

Keywords:

Snake skin, indometacin, permeation

Abstract

The potential usefulness of snake skin  Boa constrictor  as a model membrane for percutaneous drug release was examined. There are similarities between shed snake skin and human stratun corneum en terms of structure, composition, lipid content, water permeability, etc. Considering the similariries snake skin and human skin the  Boa constrictor was used as a barrier for an  in vitro permeation, the indomethacin was selected as a model of drug, indicated narrower variation of results  in coefficients of variation and reproductibility of permeation profiles.

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Published

2011-11-20

How to Cite

Nunes, R. S., Azevedo, J. R., Vasconcelos, A. P., & Pereira, N. L. (2011). Standardization study of snake skin Boa constrictor as a model membrane for percutaneous drug release. Scientia Plena, 1(7). Retrieved from https://scientiaplena.emnuvens.com.br/sp/article/view/583

Issue

Vol. 1 No. 7 (2005): October/Outubro 2005

Section

Articles

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