Inhibitory action of mycocins on airborne fungi isolated from neonatal ICU

Authors

  • Jessica Vieira Menin Laboratório de Pesquisa, Ensino e Extensão –LACEPE/ Laboratório de Micologia/ Hospital Universitário do Oeste do Paraná - Universidade Estadual do Oeste do Paraná – Unioeste
  • Jessica Cassia da Silva Laboratório de Pesquisa, Ensino e Extensão –LACEPE/ Laboratório de Micologia/ Hospital Universitário do Oeste do Paraná - Universidade Estadual do Oeste do Paraná – Unioeste
  • Rafaela de Souza Marquezoni Laboratório de Pesquisa, Ensino e Extensão –LACEPE/ Laboratório de Micologia/ Hospital Universitário do Oeste do Paraná - Universidade Estadual do Oeste do Paraná – Unioeste
  • Marilu Chaves Gomes Dresch Camargo Laboratório de Pesquisa, Ensino e Extensão –LACEPE/ Laboratório de Micologia/ Hospital Universitário do Oeste do Paraná - Universidade Estadual do Oeste do Paraná – Unioeste
  • Micaelly Hoffemann Schina Laboratório de Pesquisa, Ensino e Extensão –LACEPE/ Laboratório de Micologia/ Hospital Universitário do Oeste do Paraná - Universidade Estadual do Oeste do Paraná – Unioeste
  • Telma Barboza Paula Laboratório de Pesquisa, Ensino e Extensão –LACEPE/ Laboratório de Micologia/ Hospital Universitário do Oeste do Paraná - Universidade Estadual do Oeste do Paraná – Unioeste
  • Eloiza Cristina Martelli Laboratório de Pesquisa, Ensino e Extensão –LACEPE/ Laboratório de Micologia/ Hospital Universitário do Oeste do Paraná - Universidade Estadual do Oeste do Paraná – Unioeste
  • Marcos Ereno Auler Laboratório de Pesquisa, Ensino e Extensão –LACEPE/ Laboratório de Micologia/ Hospital Universitário do Oeste do Paraná - Universidade Estadual do Oeste do Paraná – Unioeste
  • Rita de Cassia Garcia Simão Laboratório de Pesquisa, Ensino e Extensão –LACEPE/ Laboratório de Micologia/ Hospital Universitário do Oeste do Paraná - Universidade Estadual do Oeste do Paraná – Unioeste
  • Rinaldo Ferreira Gandra Universidade Estadual do Oeste do Paraná

DOI:

https://doi.org/10.14808/sci.plena.2025.096201

Keywords:

Wickerhamomyces anomalus, antimicrobial, intensive care

Abstract

Airborne fungi, with the ability to establish themselves and contaminate the air, reduce the life quality of the organisms that circulate there. Invasive fungal nosocomial infections have progressively emerged as a relevant source of morbidity and mortality in patients, especially the immunosuppressed patients. The broad spectrum of antimicrobial activity and the great stability led to the use of Wickerhamomyces anomalus as a biocontrol agent, since it could be classified as a low-risk microorganism. The aim of the present study was to evaluate the inhibition of airborne fungi isolated in a Neonatal ICU by mycocins produced by W. anomalus. The mycocins containing W. anomalus culture supernatant showed β-glucanases activity of 4.2 U/mg. For fungal monitoring and inhibition test in solid environment, the passive sedimentation technique was used. The test consisted of a control plate containing Sabouraud Dextrose Agar, and another composed of culture medium and W. anomalus mycocins supernatant. Then, after incubation, the growth and/or inhibition of the collected fungi was observed. The growth of 15 genera was observed on the control plates: Aureobasidium spp., Curvularia spp., Emmonsia spp., Geotrichun spp., Fusarium spp., Rhizopus spp., Rhodotorula spp., Scedosporium spp., Chrysosporium spp., Trichoderma spp., Alternaria spp., Aspergillus spp., Acremonium spp., Penicillium spp. and Cladosporium spp. Cladosporium spp. was the most incident in the analyzed period, 40% (86 UFC). Meanwhile, on the test plates there was no growth of microorganisms. As a result, we can see the potential of W. anomalus mycocins in the development of new antimicrobial substances.

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Published

2025-10-14

How to Cite

Menin, J. V., da Silva, J. C., Marquezoni, R. de S., Camargo, M. C. G. D., Schina, M. H., Paula, T. B., … Ferreira Gandra, R. (2025). Inhibitory action of mycocins on airborne fungi isolated from neonatal ICU. Scientia Plena, 21(9). https://doi.org/10.14808/sci.plena.2025.096201

Issue

Vol. 21 No. 9 (2025): Setembro/September 2025

Section

Articles

License

Copyright (c) 2025 Jessica Vieira Menin, Jessica Cassia da Silva, Rafaela de Souza Marquezoni, Marilu Chaves Gomes Dresch Camargo, Micaelly Hoffemann Schina, Telma Barboza Paula, Eloiza Cristina Martelli, Marcos Ereno Auler, Rita de Cassia Garcia Simão, Rinaldo Ferreira Gandra

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