Stryphnodendron adstringens bark extracts per solvents different: chemical quantification and antioxidant activity in vitro and in silico

Abstract

Plants are considered important sources of molecules with biological potential. The objective of this investigation was to identify tannic compounds, determine antioxidant activity, parameters of PH and density, as well as the contents of soluble solids and total flavonoids, in addition to the phytochemical profile by spectrophotometry in the visible ultraviolet and molecular docking simulation between the major compounds present in plant extracts of Stryphnodendron adstringens (Mart.) Coville. The extracts were formulated using a homogeneous powder obtained by grinding the bark of S. adstringens, they were formulated at 10% (w/v) by the extractive technique of dynamic maceration. The hydroethanolic, ethanolic and methanolic extract had the highest flavonoid contents. The antioxidant activity was greater than 50% for the acetonic and aqueous extracts. The visible ultraviolet spectroscopy showed the majority presence of flavonoids for all evaluated extracts. Molecular docking simulations showed the high antioxidant potential of the major phytochemicals studied, supporting the results obtained in the in vitro assays. Therefore, considering the inherence of the other conditions observed during the extract production process, it is inferred that the choice of certain solvents can qualitatively and quantitatively influence the obtaining of certain groups of plant metabolites with biological potential in S. adstringens.