New isoflavones isolated from Vatairea guianensis Aubl. leaves and antiprolifetarive activity

Authors

  • Geilson Alcantara da Silva Universidade Federal do Pará, Centro de Ciências Exatas e Naturais, Instituto de Química, Central de Extração. https://orcid.org/0000-0002-1119-4248
  • Ronilson Freitas de Souza Universidade do Estado do Pará - UEPA
  • Victor Hugo Marinho Universidade Federal do Pará - UFPA
  • Wandson Braamcamp Pinheiro Universidade Federal do Pará - UFPA
  • Laine Celestino Pinto Universidade Federal do Pará - UFPA
  • Raquel Carvalho Montenegro Universidade Federal do Pará - UFPA
  • Alberto Cardoso Arruda Universidade Federal do Pará - UFPA
  • Milton Nascimento Silva Universidade Federal do Pará - UFPA
  • Mara Silvia Arruda Universidade Federal do Pará - UFPA

DOI:

https://doi.org/10.14808/sci.plena.2020.117201

Keywords:

Vatairea guianensis, antiproliferative activity, isoflavones

Abstract

The species Vatairea guianensis Aubl, has great importance and application in traditional medicine in the treatment of diseases caused by dermatophytic fungi, being a promising species of bioactive molecules, such as antioxidants, antifungal among others. In this context, the objective of this study was to carry out the phytochemical study and to test the cytotoxic activity in tumor strains. The fractionation of the ethanolic extract of the leaves led to the isolation and structural identification of five secondary metabolic agents belonging to the isoflavone class. Two stand out: Vatairenone A (S1) and Vatairenone B (S2), which are new natural products. Structural elucidation was performed using 1D and 2D NMR spectroscopic data, and in comparison with literature data. The substance Lupiwighteona (S3) showed selective cytotoxicity in the breast (MCF-7) and melanoma (SK-MEL-19) lines, with IC50 values 3.971 ± 0.153 and 4.677 ± 0.328 μM, without causing hemolysis in erythrocytes from mice, evaluated by the MTT method in vitro. The results are promising, being the first study of the genus Vatairea with cytotoxic activity of isoflavones from natural products.

Author Biographies

Geilson Alcantara da Silva, Universidade Federal do Pará, Centro de Ciências Exatas e Naturais, Instituto de Química, Central de Extração.

http://lattes.cnpq.br/6530835383820369

Ronilson Freitas de Souza, Universidade do Estado do Pará - UEPA

http://lattes.cnpq.br/0747461930362318

Victor Hugo Marinho, Universidade Federal do Pará - UFPA

http://lattes.cnpq.br/2869222291196173

Wandson Braamcamp Pinheiro, Universidade Federal do Pará - UFPA

http://lattes.cnpq.br/8867866033296703

Laine Celestino Pinto, Universidade Federal do Pará - UFPA

http://lattes.cnpq.br/0813179405197236

Raquel Carvalho Montenegro, Universidade Federal do Pará - UFPA

http://lattes.cnpq.br/0043828437326839

Alberto Cardoso Arruda, Universidade Federal do Pará - UFPA

http://lattes.cnpq.br/4230858175725504

Milton Nascimento Silva, Universidade Federal do Pará - UFPA

http://lattes.cnpq.br/6742390457977989

Mara Silvia Arruda, Universidade Federal do Pará - UFPA

http://lattes.cnpq.br/8047078292358267

Downloads

Published

2020-12-18

How to Cite

da Silva, G. A., de Souza, R. F., Marinho, V. H., Pinheiro, W. B., Pinto, L. C., Montenegro, R. C., … Arruda, M. S. (2020). New isoflavones isolated from Vatairea guianensis Aubl. leaves and antiprolifetarive activity. Scientia Plena, 16(11). https://doi.org/10.14808/sci.plena.2020.117201

Issue

Vol. 16 No. 11 (2020): Novembro/November 2020

Section

Articles

License

Copyright (c) 2020 Geilson Alcantara da Silva, Ronilson Freitas de Souza, Victor Hugo Marinho, Wandson Braamcamp Pinheiro, Laine Celestino Pinto, Raquel Carvalho Montenegro, Alberto Cardoso Arruda, Milton Nascimento Silva, Mara Silvia Arruda

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work

Most read articles by the same author(s)