Analysis of Protein Interaction in the Cancer Development

Abstract

The activation of genome maintenance mechanisms (MMG) pathways such as: cell cycle (CC), DNA damage response (DDR) and apoptosis (APO) significantly contribute to tumor development. In previous studies, it was found in pre-cancerous process there is activation of an anti-cancer barrier, which is responsible for prevention of tumor progression. The identification of the genes expressed during activation of the anti-cancer barrier, associated with the interactions in MMG pathways, becomes a complementarity to the study of the cancer development. In this work, the objective was to investigate the activation of the genes in the MMG pathways in pre-cancer of the adrenal gland, colon, pancreas and thyroid follicles, using networks of interaction between proteins. To describe this study was proposed the modeling interaction networks between the proteins of MMG pathways using the Cytoscape software. The results obtained with the most prominent genes in expression and quantity of interactions were compared with the results of previous publications and reconfirmed the relevance of CDKN1A, CHEK1, ATR, TP53, MRE11A and XRCC4 genes. This analysis allowed the identification of other genes complementary to previous studies as SKP2, CCNO, FADD, RAD50, NBN, BIRC3, CDK2 and XRCC6 genes. These genes are associated and complement the studies on the activation of anti-cancer barrier. These considerations highlight that it is important to note the entire biological systemic and immersive context